Natural cog extraction method
Txoj kev no tsuas yog siv cov nplooj ntoo ntawm genus Ursi ua cov khoom siv raw, thiab siv cov organic hnyav extraction, rho tawm, kem chromatography thiab lwm yam kev sib cais thiab kev huv kom tau txaisarbutin rho tawm. Thaum ntxov li xyoo 1930, nws tau tshaj tawm tiasarbutin muaj nyob rau hauv nplooj ntawm pob zeb cabbage. Cov kev tshawb fawb tom qab tau lees paub tias arbutin kuj pom muaj nyob hauv nplooj ntawm tsob ntoo dub, bilberry, bearberry thiab pear ntoo. glycosides.
Txij li thaum cov ntsiab lus ntawm arbutin nyob rau hauv cov nroj tsuag yog tsawg heev, cov txheej txheem extraction yog complex, thiab purity ntawm cov extract tsis siab, yog li nrog rau txoj kev loj hlob ntawm lwm yam kev npaj, cov nroj tsuag extraction txoj kev tau maj poob nws kev sib tw kom zoo dua.
Tsob ntoo kab lis kev cai
Cov nroj tsuag kab lis kev cai txoj kev siv lub peev xwm glycosylation ntawm cov nroj tsuag cov hlwb los hloov hydroquinone rau hauv arbutin. Piv nrog rau txoj kev rho tawm cov nroj tsuag, qhov ua tau zoo ntawm kev tau txais arbutin siv cov kab lis kev cai cog qoob loo ntau dua. Thaum siv txoj kev no, xaiv cov nroj tsuag kab lis kev cai nruab nrab thiab txiav txim siab txog kab lis kev cai tsim nyog yog qhov tseem ceeb.
T nws raw cov ntaub ntawv siv nyob rau hauv cog cov ntaub so ntswg kab lis kev cai txoj kev yog huv si, lub conversion tus nqi siab, thiab cov ntau lawm yog tsis muaj kuab paug. Txawm li cas los xij, lub voj voog ntau lawm ntev, kev sib cais thiab kev ua kom huv yog qhov nyuaj, thiab kev tsim kho kev lag luam tseem tsis paub qab hau. Ntxiv kev nkag siab txog txoj kev loj hlob ntawm cov nroj tsuag cog, qhia meej txog qhov tseem ceeb cuam tshuam ntawm cov txheej txheem synthesis, shortening lub voj voog ntau lawm, thiab kev txhim kho cov qoob loo yog cov teeb meem tseem ceeb uas yuav tsum tau daws nyob rau hauv daim ntawv thov ntawm txoj kev no.
Txoj kev enzyme synthesis
Cov txheej txheem synthesis enzyme tsuas yog siv glycosyltransferase lossis glycosidase ua cov khoom siv rau kev hloov pauv glycosyl thiab thim rov qab hydrolysis cov tshuaj tiv thaiv los ua ke glycosides, uas yog, arbutin tau txais los ntawm hydroquinone thiab qabzib hauv qab catalysis ntawm glycosidase.
Cov txheej txheem enzyme synthesis muaj cov txheej txheem yooj yim, kev ua haujlwm siab synthesis, thiab kev cia siab zoo heev. Nrog rau kev tshawb fawb tob txog cov qauv no hauv xyoo tas los no, ntau thiab ntau cov zymogens tsim nyog tau raug tshawb pom, thiab cov synthesis ntawm arbutin kuj tau nce siab dua. Nws ntseeg tau tias txoj kev no yuav yog ib qho ntawm cov kev tshawb fawb tseem ceeb rau kev sib txuas ntawm arbutin yav tom ntej. ib.
Tshuaj synthesis
Feem ntau, tshuaj synthesis ntawm arbutin siv cov piam thaj thiab hydroquinone ua raw khoom. Tom qab ob qho kev tiv thaiv tsim nyog, lawv tau txais cov tshuaj tiv thaiv glycosidation thiab tshem tawm cov pab pawg tiv thaiv. Cov txheej txheem tshuaj synthesis tau dhau los ua txoj hauv kev tseem ceeb tshaj plaws rau kev npaj arbutin vim nws qhov zoo ntawm cov khoom siv hluavtaws zoo dua thiab cov nqi qis dua, thiab tau ua tiav kev tsim khoom hauv tsev thiab txawv teb chaws.
Tam sim no, nyob rau hauv Suav teb, anhydrous qabzib feem ntau yog siv los ua raw khoom, thiabb -arbutin yog tsim los ntawm acylation tiv thaiv, catalytic condensation, thiab alkaline hydrolysis. Nrog rau kev txhim kho txuas ntxiv ntawm kev siv thev naus laus zis, nyob rau xyoo tas los no, cov kauj ruam rau kev sib txuas hauv tsev ntawm arbutin tau maj mam yooj yim, cov synthesis tus nqi tau raug txhim kho tas li, thiab qhov zoo tau mus txog qib siab thoob ntiaj teb. Txawm li cas los xij, vim qhov tsis zoo stereoselectivity ntawm cov khoom hauv cov tshuaj synthesis, kev tshawb fawb ntau dua tseem xav tau los nrhiav kev siv tau zoo thiab tshwj xeeb tshuaj synthesis rau kev npaj.ib- arbutin.
Kev nyab xeeb ntawm arbutin
Vim tias hydroquinone muaj cov nyhuv inhibiting tyrosinase, nws tau siv thaum ntxov los tiv thaiv freckle thiab whitening tshuaj pleev ib ce kom txo tau cov tawv nqaij pigmentation. Cov kev tshawb fawb tom qab pom tias hydroquinone muaj kev pheej hmoo ua rau exogenous ochronosis thiab vitiligo, nrog rau rhiab heev thiab carcinogenesis. Muaj peev xwm txaus ntshai, nws tau teev tseg raws li txwv tsis pub siv tshuaj pleev ib ce hauv kuv lub tebchaws. Arbutin kuj yog tyrosinase inhibitor thiab hloov rau hydroquinone. Nyob rau hauv tej yam kev mob xws li pH tsis tshua muaj nqi, kub siab, thiab ultraviolet irradiation, arbutin yuav hloov mus rau hydroquinone nyob rau hauv qhov kev txiav txim ntawm daim tawv nqaij kab mob los yog glucosidase, ua rau muaj kev pheej hmoo ntawm rhiab heev, genotoxicity, los yog carcinogenesis. Yog li ntawd, kev tshawb fawb txog kev nyab xeeb ntawm arbutin yeej ib txwm nyiam kev lag luam.
Thaum Lub Ob Hlis 2023, SCCS tau tshaj tawm nws qhov kev xav zaum kawg ntawm kev nyab xeeb ntawmib- arbutin thiabb-arbutin hauv tshuaj pleev ib ce (SCCS/1642/22), nrog rau cov lus xaus hauv qab no
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Post lub sij hawm: Feb-23-2024
