Xyoo 1998, Japanese kws tshawb fawb Akiu et al. muab rho tawm thiab cais tawm arbutin los ntawm nplooj bearberry thiab tau txais ib yam khoom uas tuaj yeem ua tiav cov teebmeem whitening. Nws muaj ntau yam tshuaj siv tshuaj xws li tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob, expectorant, thiab antiasthmatic. , nws kuj yog ib qho inhibitor ntawm tyrosinase nyob rau hauv tib neeg melanocytes, yog li nws sai sai ua tus hlub ntawm kev lag luam whitening.
Arbutin, tseem hu uaarbutin , yog tshuaj p-hydroxyphenyl-D-glucopyranoside thiab yog nyob rau hauv daim ntawv ntawm cov koob dawb zoo li muaju los yog hmoov. Yooj yim soluble hauv dej kub, methanol, ethanol thiab aqueous daws ntawm propylene glycol thiab glycerol, tab sis insoluble nyob rau hauv ether, chloroform, roj av ether thiab lwm yam kuab tshuaj. Cov mis mos molecular yog C12H16O7, thiab nws cov qauv yog raws li nram no:
Arbutin yog ib qho molecule uas tsim los ntawm cov organic pawg muaj li ntawm polyvalent hydroxyl pawg. Cov tshuaj aqueous yog xim tsis muaj xim thiab pob tshab, yog li nws muaj kev sib raug zoo thiab tuaj yeem siv tau yooj yim los ua ib qho ntxiv hauv cream. Tsis tas li ntawd, nws muaj cov khoom zoo moisturizing, yooj yim dua los siv nrog pleev, muaj qhov muag muag thiab xis nyob ntawm daim tawv nqaij, thiab muaj me ntsis dawb thiab huv si tom qab thov. Cov yam ntxwv no yog txiav txim los ntawm cov qauv ntawm polyhydroxyl glycosides.
Tsis tas li ntawd, arbutin muaj qhov tshwj xeeb inhibitory nyhuv ntawm melanin.
Melanin yog cov xim tsaus nti uas tuaj yeem ua rau tawv nqaij xim. Nws yog tsim los ntawm oxidation ntawm tyrosine los ntawm tyrosinase. Peb tuaj yeem suav tias tyrosinase yog qhov tseem ceeb ntawm kev txwv enzyme rau kev tsim cov melanin hauv daim tawv nqaij. Qhov kev ua ntawm tyrosine txiav txim siab npaum li cas ntawm melanin tsim.
Yuav ua li cas inhibit qhov kev ua haujlwm catalytic ntawm tyrosinase yog ib qho ntawm cov lus qhia tseem ceeb hauv kev lag luam ntxuav hniav dawb. Cov tshuaj ntxuav hniav dawb xws li hydroquinone (1,4-hydroquinone) tuaj yeem cuam tshuam kev ua haujlwm ntawm tyrosinase thiab muaj qee yam depigmentation ntawm daim tawv nqaij. Txawm li cas los xij, kev siv sab nraud tuaj yeem ua rau khaus khaus thiab tuaj yeem ua rau khaus tawv nqaij, stinging, thiab tev. Cov tsos mob ua xua xws li dandruff thiab erythema tuaj yeem ua rau muaj kev puas tsuaj mus tas li, yog li nws daim ntawv thov kev kho mob yuav raug rau qee yam kev txwv.
Cov qauv ntawm arbutin zoo ib yam li hydroquinone. Nws cov qauv muaj ib qho qabzib molecule ntau dua li hydroquinone, ua rau nws ruaj khov thiab ntau dua ntawm daim tawv nqaij. Nws kuj tseem tuaj yeem cuam tshuam tyrosinase kev ua haujlwm thiab kev tsim melanin. , tsis muajt tsuas yog tuaj yeem tshem tawm cov stains, tab sis kuj muaj qee yam kab mob bactericidal thiab tiv thaiv kab mob.
Nws muaj cytotoxicity tsawg thiab muaj kev nyab xeeb thiab tsis muaj tshuaj lom rau ntawm daim tawv nqaij. Nws tuaj yeem cuam tshuam kev ua haujlwm ntawm tyrosinase thiab tiv thaiv kev tsim ntawm melanocytes. Nws tseem tuaj yeem sib txuas ncaj qha nrog tyrosinase txhawm rau txhawm rau txhawm rau decomposition ntawm melanin. thiab emissions los txo cov deposition ntawm melanin nyob rau hauv daim tawv nqaij, yog li arbutin yog lub zoo tagnrho compound neeg tab tom nrhiav.
Raws li cov qauv sib txawv, arbutin tuaj yeem muab faib ua α-arbutin, β-arbutin thiab deoxyarbutin (D-arbutin).
Txij li thaum α-arbutin feem ntau tau txais los ntawm kev hloov pauv roj ntsha thiab kev sib xyaw ua ke, thiab cov khoom tsim muaj tsawg, feem ntau ntawm arbutin tam sim no nyob rau hauv kev ua lag luam yog β-arbutin, tab sis cov nyhuv whitening tsuas yog zoo li α-arbutin. Ib- kaum tsib.
Kev tshawb fawb qhia tau hais tias nws tsim nyog ntxiv 3% arbutin rau cov tshuaj pleev ib ce, uas yog 90% zoo nyob rau hauv depigmenting freckles, npauj npaim me ntsis thiab melanin deposits.
Ob leeg α-arbutin thiab β-arbutin yog dej-soluble, thiab ob txheej txheej lecithin qauv ntawm tib neeg epidermal cell membrane yog qhov zoo dua rau kev nqus cov rog-soluble Cheebtsam, yog li deoxyarbutin tuaj ua.
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Post lub sij hawm: Apr-12-2024
