Berberine hydrochloride

Nws muaj inhibitory teebmeem ntawm Escherichia coli, Escherichia coli, Diplococcus pneumoniae, Staphylococcus aureus, Streptococcus, Typhi thiab amoeba. Clinically, nws yog tsuas yog siv los rhuav tshem cov kab mob thiab kab mob. Nws kuj tau pom tias cov khoom no muaj cov nyhuv anti-arrhythmic. Berberine muaj kev tiv thaiv qog nqaij hlav hauv vitro thiab tuaj yeem ua rau muaj kev zais ntawm B16 hlwb; tib yam li cytarabinehydrochloridemuaj txiaj ntsig zoo hauv vitro.

Lub hom phiaj
Ib qho isoquinoline alkaloid. Cov mis mos molecular [C20H18NO4] +. Kuj tseem hu ua berberine. Nws muaj nyob hauv ntau cov nroj tsuag hauv 10 genera thiab 4 tsev neeg suav nrog Berberidaceae. Berberine tuaj yeem ua rau daj koob zoo li cov muaju los ntawm diethyl ether. Melting point 145 ℃. Soluble nyob rau hauv dej, insoluble nyob rau hauv benzene, ether thiab chloroform. Berberine yog quaternary ammonium alkaloid, thiab solubility ntawm nws cov ntsev hauv dej yog me me, piv txwv li, hydrochloride yog 1: 500 thiab sulfate yog 1: 30. Cov muaju ntawm berberine precipitated los ntawm dej los yog dilute ethanol muaj 5.5 molecules ntawm siv lead ua dej; Yog tias crystallized los ntawm chloroform, acetone los yog benzene, lawv kuj muaj cov crystallization hnyav molecules. Berberine tuaj yeem kho nrog cov alkali sib txawv kom tau txais peb hom kev sib txawv ntawm berberine: quaternary ammonium form, aldehyde form thiab cawv daim ntawv, ntawm cov quaternary ammonium daim ntawv yog qhov ruaj khov tshaj plaws. Berberine muaj cov tshuaj tua kab mob ntawm hemolytic Streptococcus, Staphylococcus aureus, Neisseria gonorrhoeae, Freundii thiab Shigella dysenteriae, thiab txhim kho phagocytosis ntawm cov qe ntshav dawb. Berberine hydrochloride (feem ntau hu ua berberine hydrochloride) tau dav siv los kho mob plab, kab mob bacillary dysentery, thiab lwm yam, thiab tseem muaj qee yam cuam tshuam rau tuberculosis, kub taub hau, mob tonsillitis thiab kab mob ua pa.

kws tshuaj
pharmacodynamics
Nws muaj cov kab mob dav dav thiab muaj cov kab mob tua kab mob ntawm ntau yam kab mob Gram-positive thiab-negative hauv vitro, suav nrog hemolytic Streptococcus, Staphylococcus aureus, thiab Vibrio cholerae. Meningococci, Shigella dysenteriae, Typhoid bacilli, Diphtheria bacilli, thiab lwm yam muaj zog inhibitory teebmeem. Lawv yog cov bacteriostatic ntawm tsawg concentrations thiab sterilizing ntawm high concentrations. Nws kuj muaj qee yam cuam tshuam rau cov kab mob khaub thuas, amoeba, leptospira, thiab tej yam kab mob ntawm daim tawv nqaij. Kev sim hauv vitro tau lees paub tias berberine tuaj yeem txhim kho lub peev xwm phagocytic ntawm leukocytes thiab daim siab reticuloendothelial system. Shigella dysenteriae, hemolytic Streptococcus, Staphylococcus aureus, thiab lwm yam yog yooj yim resistant rau cov khoom no. Tsis muaj qhov sib txawv ntawm cov khoom no thiab penicillin thiab streptomycin.

Pharmacokinetics
Kev nqus qhov ncauj tsis zoo. Tom qab txhaj tshuaj, nws nkag mus rau ntau yam hauv nruab nrog cev thiab cov ntaub so ntswg, thiab cov ntshav concentration tau khaws cia rau lub sijhawm luv luv. Cov ntshav concentration tom qab txhaj tshuaj intramuscular yog qis dua qhov tsawg kawg nkaus inhibitory concentration. Cov tshuaj yog dav faib, feem ntau nyob rau hauv lub plawv, pob txha, ntsws thiab daim siab. Lub sij hawm khaws cia hauv cov ntaub so ntswg yog luv, thiab tsuas yog ib qho kab nyob tom qab 24 teev. Feem ntau ntawm cov tshuaj yog metabolized thiab tshem tawm hauv lub cev, thiab tsuas yog tsawg dua 5% ntawm cov tshuaj tau muab tso tawm hauv daim ntawv qub hauv 48 teev.
Raws li cov ntaub ntawv tsis ntev los no, nws ntseeg tau tias cov khoom no tuaj yeem txo tus naj npawb ntawm pili nyob rau saum npoo ntawm cov kab mob, tiv thaiv cov kab mob los ntawm kev txuas mus rau tib neeg lub hlwb, thiab muaj cov nyhuv kho. Cov khoom no kuj muaj qhov cuam tshuam rau Helicobacter thiab tuaj yeem txo cov kab mob gastritis, gastric thiab duodenal ulcers.

Disabled thiab siv nrog ceev faj
Txawm hais tias nws tuaj yeem siv rau cov menyuam yaus, nws yog contraindicated rau cov menyuam yaus uas muaj keeb kwm ntawm cov piam thaj-6-phosphate dehydrogenase deficiency vim tias cov khoom no tuaj yeem ua rau hemolytic anemia thiab ua rau daj ntseg.

Kev phiv tshuaj
(1) Cov tshuaj tiv thaiv ntawm qhov ncauj tsis tshua muaj, nrog qee zaus xeev siab, ntuav, ua pob liab vog thiab tshuaj kub taub hau, uas ploj tom qab tso tseg cov tshuaj.
(2) Intravenous txhaj los yog infusion tuaj yeem ua rau muaj kev cuam tshuam xws li vasodilation, ntshav siab poob, thiab mob plawv. Hauv qhov xwm txheej hnyav, Aspen syndrome tuaj yeem tshwm sim, thiab txawm tuag. Tuam Tshoj tau tshaj tawm kev tshem tawm ntau yam kev txhaj tshuaj ntawm berberine hydrochloride.
Qee tus neeg muaj mob plab me me los yog plab tsis xis nyob, cem quav lossis raws plab.

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