Tib neeg kev laus yog txoj cai universal natural. "Biochemistry thiab Cell Biology ntawm Kev Laus" qhia txog kaum xyoo ntawm kev tshawb fawb kev laus thiab ua rau kev laus rau kev puas tsuaj oxidative thiab poob hauv NAD + qib.
Nws tuaj yeem pom tias NAD + ua lub luag haujlwm tseem ceeb hauv cov kab mob, thiab nws muaj feem cuam tshuam nrog cov kab mob sib kis thiab kab mob.
NAD + hu ua nicotinamide adenine dinucleotide, lossis coenzyme I luv luv. Nws yog dav siv nyob rau hauv ntau yam kev ua ub no ntawm lub cev hauv lub cev, yog li cuam tshuam rau lub zog rov qab, tiv thaiv oxidative kev puas tsuaj, kho DNA, tswj cov noob thiab cov genomes uas tswj kev laus hauv cov hlwb, tsis muaj zog lossis txawm kaw qee cov noob laus, yog li ua haujlwm tau zoo. kev nce qib ntawm cov kab. Hauv qab no, cia peb ua tib zoo saib ntawm:
1.Qhov tseem ceeb ntawm NAD+
Raws li ib qho ntawm cov metabolites tseem ceeb tshaj plaws hauv tib neeg lub cev, NAD + tau nyob hauv lub xeev khov kho uas muaj cov khoom siv roj ntsha, kev noj, kev ncig thiab kev puas tsuaj rau lub sijhawm ntev.
Pib los ntawm 30s, NAD + qib hauv tib neeg lub cev yuav qhia txog kev poob qis raws li cov neeg muaj hnub nyoog. Qhov txo qis hauv NAD + cov ntsiab lus hauv hlwb yuav ua rau txo qis hauv DNA kho lub peev xwm, ua kom cov DNA puas ntsoog, thiab tom qab ntawd ua rau kev puas tsuaj ntawm NAD + Cov ntsiab lus txo qis dua, ua rau lub voj voog tsis zoo ntawm kev laus sai thiab nrawm dua.
Peb hais tias NAD + koom nrog hauv kev kho DNA feem ntau vim tias nws yog lub substrate ntawm PARP tsev neeg. Nrog NAD +, PARP tuaj yeem ua nws lub luag haujlwm sib xws. Ntawm qhov tod tes, PARP kuj yog ib qho tseem ceeb "cov neeg siv khoom" ntawm NAD + hauv cov hlwb. NAD + siv los ntawm PARP hloov mus rau nicotinamide NAM, thiab tom qab ntawd ntws mus rau hauv txoj kev cawm seej, thiab NAD + tau rov ua dua nrog kev pab ntawm NAMPT, NMNAT thiab lwm yam enzymes. Thaum cov hlwb muaj kev ntxhov siab (xws li cov txheej txheem kho DNA), ntau ntawm NAD + tau tsim los ntawm txoj kev khaws cia kom muaj kev sib npaug ntawm cov khoom siv thiab kev thov.
NAD + koom nrog hauv DNA kho raws li Sirtuins substrate
Sirtuins yog ib tsev neeg ntawm cov protein deacetylase uas muaj 7 tus tswv cuab (SIRT1-SIRT7). SIRT1, SIRT6, thiab SIRT7 muaj nyob rau hauv lub nucleus, SIRT2 plays lub luag hauj lwm nyob rau hauv lub cytoplasm, thiab SIRT3, SIRT4, thiab SIRT5 yog mitochondrial proteins. Qee Sirtuins (tshwj xeeb tshaj yog SIRT1 thiab SIRT6) ua lub luag haujlwm tseem ceeb hauv DNA kho thiab cellular metabolism tom qab DNA puas.
3.NAD + cov metabolism thiab kev ua haujlwm ntawm lub cev
01. Khaws cov tshuaj redox homeostasis
Kev tswj hwm qhov sib npaug ntawm cov oxidants intracellular thiab antioxidants yog tus yuam sij rau cov hlwb kom tswj lub cev muaj zog. Txawm li cas los xij, cov kev xav tsis zoo xws li kev ua qias tuaj, kev hloov pauv khoom noj khoom haus thiab kev kis kab mob tuaj yeem cuam tshuam qhov kev tshuav nyiaj li cas thiab ua rau muaj kev puas tsuaj rau cov macromolecules lom xws li DNA thiab cov proteins. Ntxiv NAD + tuaj yeem ua lub luag haujlwm tiv thaiv oxidative los ntawm kev nce qib thiab kev ua ub no ntawm glutathione thiab ntau cov enzymes antioxidant.
02. Tswj genome stability
Tsis muaj NAD + yuav ua rau muaj kev cuam tshuam rau kev kho DNA puas, ua rau muaj ntau qhov DNA puas tuaj yeem khaws cia, thiab ntxiv NAD + tuaj yeem pab kho DNA.
03 ib. Tswj kev tiv thaiv kab mob thiab kab mob
Ntxiv nrog rau NAD + nws tus kheej tuaj yeem ua kom qeeb qeeb ntawm qhov mob ntau dhau los ntawm kev txhim kho lysosomal muaj nuj nqi, NAMPT enzyme tsim nyog hauv nws cov metabolism kuj yog ib feem tseem ceeb ntawm kev tswj kev tiv thaiv kab mob. Ntxiv NAD + pab tswj kev tiv thaiv kab mob thiab mob.
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Post lub sij hawm: Dec-26-2023
