NAD Pre-Cursor qhia

NAD + yog ib qho tseem ceeb coenzyme, nws lub npe tag nrho yog nicotinamide adenine dinucleotide. Nws muaj nyob rau hauv cov hlwb thiab koom nrog ntau yam tseem ceeb ntawm cov tshuaj biochemical. NAD + ua lub luag haujlwm tseem ceeb hauv ntau cov txheej txheem lom neeg, suav nrog lub zog metabolism, kev ua pa ntawm tes, kho DNA, hloov cov noob, thiab kev laus. Nws tuaj yeem nce lossis tso tawm cov hluav taws xob los ntawm nws los ntawm ntau yam biocatalytic cov tshuaj tiv thaiv. Hauv cov txheej txheem no, cov tshuaj tiv thaiv uas NAD + tuaj yeem ua rau muaj xws li redox, carbonyl txo, acyl hloov, thiab lwm yam. Raws li coenzyme, NAD + lub luag haujlwm tseem ceeb yog hloov cov electrons thiab hydrogen ions hauv cov tshuaj tiv thaiv enzyme-catalyzed. Thaum lub sijhawm txheej txheem no, NAD + txo qis rau NADH, yog li muab cov khoom siv hluav taws xob thiab hydrogen ions rau lwm qhov kev xav tau enzyme. NAD + kuj tau txais kev saib xyuas kev tshawb fawb ntau hauv xyoo tas los no vim tias nws tau xav tias yuav koom nrog kev laus. Cov kev tshawb fawb tau pom tias thaum lub sij hawm kev laus, theem ntawm NAD + hauv hlwb txo qis, thiab ntxiv NAD + tuaj yeem txhawb nqa cellular zog metabolism, kho DNA thiab ncua kev laus. Tsis tas li ntawd, NAD + kuj tau pom los ua lub luag haujlwm tseem ceeb hauv kev kho DNA puas, apoptosis, ua kom cov enzymes thiab tswj cov noob qhia. Tam sim no, tib neeg tab tom ua qhov kev tshawb fawb tob txog NAD + thiab nws lub luag haujlwm hauv physiology thiab pathology, txhawm rau nrhiav pom ntau ntxiv txog cov haujlwm thiab kev siv ntawm NAD +.