Hais txogua berberine , txhua leej txhua tus yuav tsis paub me ntsis, tab sis txhua tus neeg yuav tsum paub cov lus hais: Ib tug neeg ruam noj coptis - nws tsis tuaj yeem qhia qhov mob! Yog lawm, lub ntsiab lus iab hauv coptis yog berberine, uas yog berberine hydrochloride.
Berberine (BBR) yog ib qho isoquinoline alkaloid - C20H19NO5 muab rho tawm los ntawm Coptis chinensis. Nws muaj nyob hauv cov nroj tsuag ntawm 10 genera thiab 4 tsev neeg suav nrog Berberidaceae. Yellow koob-puab crystals tuaj yeem ua los ntawm diethyl ether, nrog rau qhov kub ntawm 145 ° C. Lawv soluble hauv dej thiab insoluble hauv benzene, diethyl ether thiab chloroform.
Kev tshawb fawb tshuaj niaj hnub no tau lees paub tias berberine muaj qhov tseem ceeb los tiv thaiv lub plawv tsis ua haujlwm, tiv thaiv arrhythmia, txo cov roj cholesterol, tiv thaiv cov leeg nqaij du, txhim kho insulin tsis kam, tiv thaiv platelet, tiv thaiv kab mob thiab lwm yam teebmeem. Yog li ntawd, nws yuav pab tau rau cov kab mob plawv thiab paj hlwb. Nws qhov dav thiab tseem ceeb ntawm daim ntawv thov kev cia siab tau ua rau muaj kev nyiam ntau ntxiv. Raws li kev tshawb fawb soj ntsuam tshiab, berberine muaj cov txiaj ntsig zoo ntawm kev tiv thaiv thiab kho ntshav siab, hyperlipidemia, ntshav qab zib, arrhythmia, qog thiab lwm yam kab mob. Berberine hydrochloride tau tshaj tawm feem ntau hauv kev txo cov ntshav lipids. BBR tuaj yeem tswj hwm qhov kev qhia ntawm cov lipoprotein tsawg-density receptor LDLR thiab txhawb kev nqus ntawm LDL protein los ntawm daim siab hlwb. BBR hloov mus rau hauv dihydroberberine (dhBBR) los ntawm nitroreductase ntawm plab hnyuv microbiota, ua rau nws yooj yim nqus los ntawm cov hnyuv. Tom qab nqus tau, nws tau oxidized rau hauv BBR hauv plab hnyuv thiab nkag mus rau hauv cov ntshav. Ua kom cov lipid-txo qis thiab cov teebmeem hypoglycemic. BBR kuj tuaj yeem txhim kho lub zog metabolism. Kev tswj hwm qhov ncauj ntawm BBR ua rau lub plab microbiota tsim cov butyrate, uas nkag mus rau hauv cov ntshav thiab ua rau SCFAs (cov saw luv luv fatty acids), txo cov ntshav lipids thiab cov ntshav qab zib.
BBR tuaj yeem txhawb kev tsim kho ntawm pancreatic islet hlwb thiab muaj txiaj ntsig zoo dua li lwm cov tshuaj tiv thaiv ntshav qab zib. Cov kev sim tshuaj uas cuam tshuam tau ua pov thawj tias berberine tuaj yeem inhibit myocardial fibrosis hauv cov nas mob ntshav qab zib; BBR muaj cov nyhuv anti-platelet, tuaj yeem nce cov ntsiab lus nucleotide hauv platelets thiab inhibit aggregation. Berberine ua ke nrog statins ua lub luag haujlwm tseem ceeb hauv kev ua kom cov ntshav plasma trimethylamine oxidation nyob rau hauv cov kab mob plawv thiab inhibiting kev tsim ntawm atherosclerosis.
Suav berberine yog lwm txoj hauv kev zoo rau "statin" tshuaj. Txij li thaum berberine yog kaum ob lub sij hawm pheej yig dua li "statins" tshuaj, qhov kev tshawb pom ntawm berberine cov ntshav-lipid-txo cov nyhuv muaj qhov tsis muaj txiaj ntsig rau kev tiv thaiv thiab kho cov ntshav qab zib mellitus, ntshav qab zib thiab kab mob plawv.
【hu rau peb】
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Post lub sij hawm: Jan-08-2024
